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	Provedor de dados Biol. Res. (1) Autor Li,Xuan (1) Qiao,Tiankui (1) Xu,Guoxiong (1) Yuan,Sujuan (1) Zhuang,Xibing (1) Palavra-chave Acute radiation-induced lung injury (1) CpG ODN (1) Reactive oxygen species (1) Tipo do documento Journal article (1) Ano 2016 (1) País Chile (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Effects of CpG oligodeoxynucleotide 1826 on acute radiation-induced lung injury in mice Biol. Res. Li,Xuan; Xu,Guoxiong; Qiao,Tiankui; Yuan,Sujuan; Zhuang,Xibing. BACKGROUND: The radiation-induced lung injury is a common complication from radiotherapy in lung cancer. CpG ODN is TLR9 activator with potential immune modulatory effects and sensitization of radiotherapy in lung cancer. This study aimed to examine the effect of CpG ODN on acute radiation-induced lung injury in mice. METHODS AND RESULTS: The mouse model of radiation-induced lung injury was established by a single dose of 20 Gy X-rays exposure to the left lung. The results showed that the pneumonia score was lower in RT+CpG group than in RT group on 15th and 30th days. Compared with RT group, CpG ODN reduced the serum concentrations of MDA (P < 0.05) and increased the serum concentrations of SOD, GSH (P < 0.05). The serum concentration of... Tipo: Journal article Palavras-chave: CpG ODN; Acute radiation-induced lung injury; Reactive oxygen species. Ano: 2016 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100008 Registros recuperados: 1 Primeira ... 1 ... Última

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